SY09-4SYSTEMATIC REVIEW OF CASE REPORTS AND CASE SERIES ON NEW PHARMACOLOGICAL APPROACHES TO ALCOHOL USE DISORDERS

Abstract

Alcohol Dependence (AD) is a major public health being the third leading cause of morbidity worldwide. Pharmacological treatment for AD is effective and cost-saving. Nowadays, there are only four approved drugs to treat AD in Europe (nalmefene, naltrexone, disulfiram and acamprosate). However, there are some other drugs which have shown a good safety profile and effectiveness in open-label studies and double blind placebo-controlled trials (as an example: gabapen-tine or topiramate). Some other new agents proposed were under clinical o preclinical trials (baclofen, oxibate sodium, ondasetron, varenicline, ondasetron/topiramate combination, ABT-436-selective vasopressin receptor antagonist-, LY2940094-NOC-1 antagonist-, and piogliatazone). Studies with less clinical evidence should be taken also into consider-ation because they bring us closer to clinical practice. Case reports and case series of off-label pharmacological approaches for AD are frequently reported in literature and appear as a first step of preclinical and clinical research. We will present results of a systematic review of new AD pharmacological treatments including literature on this grey zone of research (case reports and cases series) published in the last 3 years.