Proton pump-inhibiting drugs, calcium homeostasis, and bone health

Abstract

Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available without a prescription. Two recent studies have demonstrated increased hip fracture rates associated with PPI use. Theoretically, PPIs could impair intestinal calcium absorption resulting in increased rates of bone loss and a greater risk of fragility fracture. © 2008 International Life Sciences Institute.