Lower Dopamine D 2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs

  • Sheng Y
  • Filichia E
  • Shick E
  • et al.
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Abstract

We report the decreased expression level of dopamine D2 receptors in human dopaminergic neurons generated from opioid-dependent induced pluripotent stem cells (iPSCs) compared with dopaminergic neurons gener- ated from a comparison group of iPSCs. We also report the expression of kappa and delta but not mu opioid receptor subtypes

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Sheng, Y., Filichia, E., Shick, E., Preston, K. L., Phillips, K. A., Cooperman, L., … Luo, Y. (2016). Lower Dopamine D 2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs. American Journal of Psychiatry, 173(4), 429–431. https://doi.org/10.1176/appi.ajp.2015.15121545

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