Synthesis, characterization and in vitro antitubercular and antimicrobial activities of new aminothiophene schiff bases and their Co(II), Ni(II), Cu(II) and Zn(II) metal complexes

Abstract

Two new clinically active Schiff bases and their transition metal complexes were synthesized and studied by different spectroscopic and physicochemical methods like NMR, IR, UV-visible, ESR, TGA, XRD, mass, elemental analysis, molar conductivity and magnetic susceptibility measurement. Synthesized complexes and Schiff bases were assessed for In vitro antituberculosis activity against Mycobacterium tuberculosis (ATCC-27294) and for antimicrobial activity against drug resistant (ESBL) Extended Spectrum ß-lactamase and (MBL) Metallo ß-lactamase producing microbial strains. The biological activity of Schiff base was found to improve in presence of transition metal ions. Among the studied metal complexes, copper complexes displayed superior biological activity against all of the microbial strains.