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A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer

Nature Communications (2024) 15(1)
DOI: 10.1038/s41467-024-46492-5
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Abstract

POU2AF2 is a co-activator of POU2F3 in normal and neoplastic tuft cells, such as small cell lung cancer. Here, the authors report that POU2AF2 dictates opposing transcriptional regulation at distal enhance elements.

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Szczepanski, A., Tsuboyama, N., Lyu, H., Wang, P., Beytullahoglu, O., Zhang, T., … Wang, L. (2024). A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-46492-5

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