Copper-catalyzed trifluoromethylation of alkenes: Synthesis of trifluoromethylated benzoxazines

Abstract

A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through tandem C-O and C-CF 3 bond formations. Furthermore, synthesized benzoxazines were selectively converted into trifluoromethylated allylic and (E)-vinylic benzamides by the treatment of KO t Bu and CH 3 Li, respectively.