Toward the synthesis of the antibiotic tetrodecamycin

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Abstract

We report here a short approach to a tricyclic substructure of tetrodecamycin exhibiting a unique ring skeleton utilising an acid catalysed ring closure as the key step. In addition an efficient three-step synthesis of 5-alkylidene 4-methoxy-2(5H)-furanones starting from 4-methoxy-2(5H)-furanone is described. (C) 2000 Elsevier Science Ltd.

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Paintner, F. F., Bauschke, G., & Kestel, M. (2000). Toward the synthesis of the antibiotic tetrodecamycin. Tetrahedron Letters, 41(51), 9977–9980. https://doi.org/10.1016/S0040-4039(00)01809-8

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