Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata

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Abstract

We studied the ability of five echinocandin-susceptible C. glabrata isolates to acquire in vitro resistance to anidulafungin and micafungin. All isolates became phenotypically resistant after 2-4 days of exposure to low and constant micafungin concentrations (P

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Bordallo-Cardona, M. Á., Escribano, P., Marcos-Zambrano, L. J., Díaz-García, J., De La Pedrosa, E. G., Cantón, R., … Guinea, J. (2018). Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata. Medical Mycology, 56(7), 903–906. https://doi.org/10.1093/mmy/myx124

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