Towards a computer aided diagnosis system dedicated to virtual microscopy based on stereology sampling and diffusion maps

Abstract

An original strategy is presented, combining stereological sampling methods based on test grids and data reduction methods based on diffusion maps, in order to build a knowledge image database with no bias introduced by a subjective choice of exploration areas. The practical application of the exposed methodology concerns virtual slides of breast tumors. © 2011 Belhomme et al; licensee BioMed Central Ltd.