Decreased perifoveal sensitivity detected by microperimetry in patients using hydroxychloroquine and without visual field and fundoscopic anomalies

Abstract

Purpose: To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods: Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results: No significant differences were found in mean MP foveal sensitivity between groups P=0.18. However, mean MP overall sensitivity was significantly higher in group A (29.05±0.57 dB versus group B, 26.05±2.75 dB; P<0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated P<0.001. Conclusion: Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.