Genetic diversities of MT-ND3 and MT-ND4L genes are associated with high-altitude adaptation

Abstract

Mitochondria can produce the energy currency of the cell through respiration which would be affected by variation in mitochondrial DNA (mtDNA). We sequenced MT-ND3 and MT-ND4L genes in 51 Tibetan yaks, 59 Tibetan cattle, and 60 Holstein-Friesian. And the results showed that the SNPs (m.9893 A > G, m.9932 A > C, and m.10155 C > T) of MT-ND3 had negative associations with high-altitude adaptation (p T was positively associated with high-altitude adaptation (p <.0017).