Cancer immunotherapy by utilizing dedritic cells derived from pluripotent stem cells

Abstract

It was recently revealed that ES-cell like pluripotent stem cells, designated as iPS cells, can be generated from so- matic cells. iPS cells could be used as not only a source of regeneration medicine, but also a source of cell vaccine. Pluripotent stem cells are characterized by pluripotency and in?nite propagation capacity. Non-virus-mediated methods for gene transfer have been established. Genetic modi?cation of pluripotent stem cells and subsequent in vitro di?erentiation to dendritic cells would be an attractive strategy. Here we describe the previous studies about cancer im- munotherapy by utilizing dendritic cells derived from pluripotent stem cells. © 2011 The Japan Society for Clinical Immunology.