The use of non-uniform deuterium labelling ['NMR-window'] to study the NMR structure of a 21 mer RNA hairpin

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Abstract

The first synthesis of a non-uniformly deuterium labelled 21 mer RNA is reported using our 'NMR-window' concept, showing its unique application in the unambiguous NMR assignment of the non-exchangeable aromatic and sugar protons.

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Földesi, A., Yamakage, S. I., Nilsson, F. P. R., Maltseva, T. V., & Chattopadhyaya, J. (1996). The use of non-uniform deuterium labelling [’NMR-window’] to study the NMR structure of a 21 mer RNA hairpin. Nucleic Acids Research, 24(7), 1187–1194. https://doi.org/10.1093/nar/24.7.1187

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