Rhodium-catalyzed cyclopropenation of alkynes: Synthesis of trifluoromethyl-substituted cyclopropenes

Abstract

(Figure Presented) Make it strained and fluorinated! A rhodium-catalyzed domino diazotization/ cyclopropenation reaction involving trifluoroethylamine hydrochloride and alkynes has been developed for the synthesis of trifluoromethyl cyclopropenes that can be easily functionalized to afford useful CF3- containing building blocks for drug discovery. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA, Weinheim.