Objective: Validate a model of high-fat diet-induced obesity, of low cost, easy reproducibility, that could express characteristics observed in human, and would enable subsequent therapy proposals. Materials and methods: Sixteen Swiss mice received a standard diet (DP) or high-fat diet (DH) for 10 weeks. Results: Although the DP group had greater water (p < 0.01) and feed (p < 0.001) consumption, the DH group had greater body weight (p < 0.5) and adipose tissue gain (p < 0.001), favoring higher adiposity index (p < 0.001), glucose (p < 0.01), and area under the curve in the insulin (p < 0.001) and glucose (p < 0.01) tolerance tests. Conclusion: A high-fat diet-induced obesity model has been validated, which was also associated with insulin resistance and glucose intolerance after a period of 10 weeks.
CITATION STYLE
White, P. A. S., Cercato, L. M., Araújo, J. M. D., Souza, L. A., Soares, A. F., Barbosa, A. P. O., … Brito, L. C. (2013). Modelo de obesidade induzida por dieta hiperlipídica e associada à resistência à ação da insulina e intolerância à glicose. Arquivos Brasileiros de Endocrinologia e Metabologia, 57(5), 339–345. https://doi.org/10.1590/S0004-27302013000500002
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