Terahertz spectroscopic identification of pharmaceutical crystals: Cocrystals and polymorphic forms

Abstract

Terahertz radio waves have about the same energy level as the non-covalent bonds between molecules, so they can be used in a spectroscopic technique for identifying differences in molecular networks. We introduce terahertz spectroscopy as a revolutionary technique for visualizing the molecular bonds in various forms of pharmaceutical crystals such as cocrystals and polymorphic forms that are closely related to crystal properties that have not yet been understood. Examples of such properties include solubility and systemic absorption rate.