Efficacy of Duloxetine on the Duration of Spinal Anesthesia and Acute Post-Operative Pain after Hip Surgery Prospective Randomized Controlled Study

Abstract

Background: Prevention and treatment of post-operative pain continue to be a major challenge in post-operative care. Preemptive analgesia has been shown to be effective in reducing the severity of post-operative pain. Serotonin and norepinephrine are involved in the modulation of endogenous analgesic mechanisms, Duloxetine is a selective Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) mainly used in the treatment of depression, anxiety and chronic pain. The analgesic effect of duloxetine is believed to result from increased activity of serotonin (5-HT) and Norepinephrine (NE) within the CNS.