N-methyliminodiacetic acid as a simple and highly efficient ligand for palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides

Abstract

A simple, air-stable, inexpensive and easily prepared molecule, N-methyliminodiacetic acid (MIDA), is reported as a ligand for palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of phenylboronic acid with aryl chlorides. The yield of the corresponding Suzuki coupling reaction is up to around 90% at both high temperature of 80°C and room temperature under ambient atmosphere.