The role of lipotoxicity in cardiovascular disease

Abstract

Fatty acids are the primary fuel for cardiac muscle. The physiological equilibrium of lipid uptake and oxidation may aid in the prevention of excessive lipid accumulation. Several pathological states, such as myocardial ischemia, obesity, and insulin resistance, are routinely associated with disorders of lipid metabolism. There is growing evidence that certain types of lipids trigger cardiac lipotoxicity and ultimately heart failure. This review focuses on recent advances in the pathogenesis of lipotoxic cardiomyopathy and the treatment prospects for the repair of cardiac damage caused by lipotoxicity.