Survival and prognostic factors for cervical cancer: a hospital based study in Mysuru, India

Abstract

ABSTRACT Background: Cervical cancer is an important cause of morbidity and mortality among women and India has the largest burden of cervical cancer patients in the world. Survival studies measure the overall performance of patients after diagnosis or treatment. Knowledge of survival is essential to design strategies for prolonging the life of cervical cancer patients. The objectives of the study were to determine the survival rate and prognostic factors for cervical cancer. Methods: This combined prospective and retrospective study was conducted during January 2012 to December 2012 among all the newly diagnosed cervical cancer patients from January 2006 to December 2007 at a tertiary care cancer hospital. Baseline data was collected by reviewing the medical records and cases were followed up for the next five years from the date of diagnosis to assess their survival status. Data was entered in Microsoft Excel and analyzed using SPSS 18. Survival analysis was done using the Kaplan Meier method. The Cox proportional hazards regression model was used to find the prognostic factors associated with cervical cancer. Results: Among the 380 cervical cancer patients, overall survival rate was found to be 48.1%, 38.7% were dead and 13.2% lost to follow up. Age at diagnosis, performance status at presentation, staging and treatment duration were the prognostic factors for cervical cancer. Conclusions: Five year survival rate for cervical cancer was found to be 48.1%. The prognostic factors of cervical cancer were potentially modifiable