Peptidoglycan recognition proteins: Players in inflammation, ageing and ageing-associated diseases: an insight from Drosophila

Abstract

Peptidoglycan recognition proteins (PGRPs), belonging to the pattern recognition molecules, are important players in the innate immune system. The function of PGRPs in antimicrobial defense are conserved from insects to mammals. In this review, we discussed the basic function of PGRPs in Drosophila and mammals. Then the association of PGRPs with inflammation, ageing and age-related disease has been narrated. The review concludes with the role of PGRP-SC2’s lifespan promoting effect in Drosophila and casts new insights of PGRPs in promoting health span in mammals.