Synthesis 4-Piperoilmorpholine from Piperine

Abstract

Piperine was isolated from black pepper by soxhletation method using technical grade ethanol as a solvent. This compound was used as precursor for the synthesis of 4-piperoilmorpholine. The synthesis was carried out via a pre-target piperoilchloride, where the piperine was initially hydrolyzed using KOH ethanolate for 24 hours, added SOCl2 and then mixed with morpholine at 0-5° C. The result of synthesis was obtained 4-piperoilmorpholine with yield of 40,80%.