Trifluoroacetic acid as an effective catalyst for biginelli reaction: One-pot, three-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones (and-thiones)

Abstract

Trifluoroacetic acid (TFA) is introduced as an effective catalyst for promotion of Biginelli reaction. 3,4-Dihydropyrimidin-2(1H)-one (-thione) derivatives (DHPMs) were simply and efficiently prepared using TFA catalyzed one-pot, three-component condensation β-dicarbonyl compounds, aldehydes and urea (thio).