A new 5α,8α-epidioxysterol from the soft coral Sinularia gaweli

Abstract

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24- methylcholest- 6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en- 3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues. The cytotoxicity of sterols 1-3 towards various tumor cells is reported.