High-intensity resistance training suppresses exacerbation of atopic dermatitis in mice

Abstract

PURPOSE: Training generally promotes health and inhibits diseases. However, in patients with atopic dermatitis (AD), training and sweating are significant aggravating factors. This study examined the effect of high-intensity resistance training (HIRT) on AD-like skin lesions in mice. METHODS: Eight-week-old female BALB/c mice were divided into four groups (control, HIRT, AD-only, and AD+HIRT). The mice in the HIRT group performed vertical ladder climbing for four weeks. RESULTS: After four weeks of HIRT, histopathological examination revealed reduced epidermis/dermis and dermal infiltration of inflammatory cells in the mice ear tissue. Additionally, HIRT suppressed serum immunoglobulin (Ig) levels and mRNA expression of pathogenic cytokines in the ear tissue; further, it reduced the size and weight of the draining lymph node (dLN) and non-dLN (ndLN), and the pathogenic cytokine-related mRNA expression of CD4+T cells from dLNs and ndLNs. We thus observed a negative correlation between HIRT and AD symptoms in mice. CONCLUSIONS: The results show that HIRT exerts positive effects in patients with AD.