Progress in Nanomaterials-based Electrochemical Biosensors for Beta-amyloid Peptides as the Biomarkers of Alzheimer's Disease

Abstract

Alzheimer's disease (AD) have affected the older population worldwide through the rapid decline in cognitive impairment. Mounting evidence suggest that beta-amyloid peptide (Aβ) and its derivates are closely related to the emergence and growth of AD. Thus, the specific and sensitive detection of Aβ species have an important role in the early diagnosis of AD. Electrochemical method is a promising candidate for bioassays. The current review mainly focuses on the development of nanomaterials-based electrochemical biosensors for Aβ species in the past decades. We cover the comprehensive utilization of nanomaterials in biosensor construction as the electrode substrate and signal reporters.