Erythromycin a oxime 11,12-carbonate and its oxime ethers

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Abstract

Erythromycin A oxime 11, 12-carbonate (5a) and its oxime ethers 5b-5p have been prepared and their antibacterial activities compared with those of erythromycin A (1) and. its 11, 12-carbonate 2. The oxime 5a and many of its oxime ether derivatives showed good activity in vitro against Gram-positive and the more permeable Gram-negative organisms, in some cases being even more active than the carbonate 2. © 1989, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Brain, E. G., Forrest, A. K., Hunt, E., Shillingford, C., & Wilson, J. M. (1989). Erythromycin a oxime 11,12-carbonate and its oxime ethers. The Journal of Antibiotics, 42(12), 1817–1822. https://doi.org/10.7164/antibiotics.42.1817

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