Virus attachment and replication are promoted after acquisition of host CD28 and CD152 by HIV-1

Abstract

CD28 is constitutively expressed on CD4+ cells, but its homologue CD 152 is only weakly expressed after cell activation. To determine whether these 2 costimulatory molecules can be inserted into human immunodeficiency virus type 1 (HIV-1), virus was produced in CD28- and CD152-expressing Jurkat-derived cells. Both molecules were efficiently acquired by virions. Virus attachment and infectivity were more affected by CD152 than by CD28. Given that CD28/CD152-CD80/ CD86 interactions play a dominant role in antigen presentation, it can thus be proposed that the association between virus-anchored host CD28/CD152 and cell-surface CD80/ CD86 on target cells might have consequences for the transmission and pathogenesis of HIV-1. © 2005 by the Infectious Diseases Society of America. All rights reserved.