Effect of mannose-binding protein on binding of Cryptococcus neoformans to human phagocytes

Abstract

The capacity of human peripheral blood monocytes, neutrophils, and monocyte-derived macrophages to bind the yeast Cryptococcus neoformans was increased when the phagocytes were cultured on surfaces containing recombinant human mannose-binding protein. In contrast, soluble mannose- binding protein had no effect on cryptococcal binding by phagocytes.