Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage

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Abstract

A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.

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Xia, J., Chiu, L. Y., Nehring, R. B., Bravo Núñez, M. A., Mei, Q., Perez, M., … Rosenberg, S. M. (2019). Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. Cell, 176(1–2), 127-143.e24. https://doi.org/10.1016/j.cell.2018.12.008

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