Integrator: A guardian against RNA-induced chaos

Abstract

In the June 12th issue of Cell, Baluapuri et al.1 report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early and late consequences of INT depletion, the study exemplifies how transcriptional dysregulation can culminate in profound physiological outcomes.