Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells

Abstract

Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts. Copyright © 2007, American Society for Microbiology. All Rights Reserved.