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Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions

Angewandte Chemie - International Edition (2013) 52(23) 6059-6062
DOI: 10.1002/anie.201300640
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Abstract

Losing ligands rapidly: PtIV complexes with haloacetato ligands can hydrolyze rapidly under biological conditions (pH7 and 37 °C, see scheme) and the rate increases with increasing pH value. Possible mechanisms for this hydrolysis are examined using H218O and ESI-MS analysis. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Wexselblatt, E., Yavin, E., & Gibson, D. (2013). Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions. Angewandte Chemie - International Edition, 52(23), 6059–6062. https://doi.org/10.1002/anie.201300640

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