Microneedling and injectable-Platelet Rich Fibrin for Skin Rejuvenation and Regeneration

Abstract

Aim: The aim of this systematic review is to evaluate the efficacy of microneedling treatment with injectable-platelet-rich fibrin (i-PRF) for facial skin rejuvenation applications. Methods: The search approach involved the exploration of electronic databases with an advanced search option applied from April 2021 to April 2025 according to our previous study Vesala et al. We performed a search on Medline, Scopus, Embase, and Web of Science. Our online search conducted according to the following PICO framework: (microneedling) AND (or) OR (needling) OR (face rejuvenation) OR (skin rejuvenation) OR (facial regeneration) AND (injectable platelet-rich fibrin) OR (i-PRF). Results: The search yielded 2 studies. Both proving that the combination of microneedling and injectable-Platelet Rich Fibrin enhances the patients' skin texture, color, elasticity, accompanied by a visible reduction in the appearance of soft wrinkles and also leads to the improvement of acne scars. Conclusion: The findings from these studies have been systematically reviewed, offering a comprehensive understanding of its efficacy and safety profile. Overall, the findings from existing studies are promising; therefore, there is a pressing need for further research to provide more robust evidence and validate the observed outcomes.