Edge-centric network control on the human brain structural network

Abstract

Network control theory models how gray matter regions transition between cognitive states through associated white matter connections, where controllability quantifies the contribution of each region to driving these state transitions. Current applications predominantly adopt node-centric views and overlook the potential contribution of brain network connections. To bridge this gap, we use edge-centric network control theory (E-NCT) to assess the role of brain connectivity (i.e., edges) in governing brain dynamic processes. We applied this framework to diffusion MRI data from individuals in the Human Connectome Project. We first validate edge controllability through comparisons against null models, node controllability, and structural and functional connectomes. Notably, edge controllability predicted individual differences in phenotypic information. Using E-NCT, we estimate the brain’s energy consumption for activating specific networks. Our results reveal that the activation of a complex, whole-brain network predicting executive function (EF) is more energy efficient than the corresponding canonical network pairs. Overall, E-NCT provides an edge-centric perspective on the brain’s network control mechanism. It captures control energy patterns and brain-behavior phenotypes with a more comprehensive understanding of brain dynamics.