A non-invasive method for biological age estimation using frailty phenotype assessment

Abstract

The human body has two different ages: a Chronological Age (CA), the actual time a person has been alive, and a Biological Age (BA), the real age that indicate the decline in health and in function ability during aging. Among previous studies, some authors proposed methodologies to estimate the Biological Age starting from non-invasive frailty measurements to evaluate the Frailty Index, others proposed invasive and expensive methods to measure the biological aging. Conversely, in this paper we propose a method to estimate the BA of a subject based on the assessment of the Frailty Phenotype. This type of evolution allows an efficient estimation of the frailty in contrast with the Frailty Index which is composed by a long checklist of clinical conditions and diseases to be evaluated from medical staff. We developed a cloud application, able to store and elaborate the data acquired during the evaluation protocol of the Frailty Phenotype, and also able to automatically provide the state of phenotypic fragility, and finally the Biological Age of a subject.