Syntheses of heteroaryl-benzotriazoles by mannich condensations

Abstract

Efficient one step syntheses of N-substituted-2-(benzotriazol-1-yl) [isoindoles and pyrroles] are effected by reactions of primary amines with o-phthalaldehyde and 2,5-dimethoxy-2,5-dihydrofuran, respectively, in the presence of benzotriazole. Reaction of 2,5-dimethoxy-2,5-dihydrofuran with benzotriazole gave 2-(benzotriazol-1-yl)furan.