Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile.
CITATION STYLE
Sánchez, B., Calderón, C., Tapia, R. A., Contreras, R., & Campodónico, P. R. (2018). Activation of electrophile/nucleophile pair by a nucleophilic and electrophilic solvation in a SNAr reaction. Frontiers in Chemistry, 6(OCT). https://doi.org/10.3389/fchem.2018.00509
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