Formulation and Evalution of Oral Reconstitutable Suspension of Cefpodoxime Proxetil

Abstract

Cefpodoxime proxetil (CFPD PRXL) is broad spectrum, third generation cephalosporin; antibiotic. It is extremely bitter taste resulting in poor patient compliance. The aim of the present work was to prepare drug resin complex (DRC) using ion exchange resin (Kyron T-114) for taste masking and formulate oral reconstitutable suspension of DRC. DRC was evaluated for effect of variables like drug:resin ratio, pH, temperature, soaking time of resin, & stirring time. Reconstitutable suspension was prepared using Xanthun gum and microcrystalline cellulose as suspending agents. Formulated reconstitutable suspension was evaluated for before reconstitution parameters like flow properties, particle size and drug content and after reconstitution parameters like aesthetic appeal, sedimentation rate, redispersibility, particle size, viscosity, pH and drug content. Formulated CFPD PRXL reconstitutable suspension has acceptable sedimentation properties. In evaluating period of 14 days no significant change was observed in pH, viscosity, particle size and drug content. From the results it is concluded that effective taste masking of Cefpodoxime proxetil was achieve using Kyron T-114 and successfully evaluated in reconstitutable suspension.