Comparison and analysis of statins drug use in the treatment of diastolic dysfunction in patients

Abstract

Statins have multiple anti lipid effects, such as anti-inflammatory, anti-oxidation and anti arteriosclerosis, which are beneficial to improve cardiac function. Statins can effectively improve left ventricular remodeling and protect ventricular diastolic function. In this study, the effects of statin therapy on diastolic function and BNP level and exercise tolerance after exercise were observed by statins in patients with diastolic dysfunction. The results showed that after atorvastatin treatment, the exercise BNP decreased in the treatment group, which was significantly different from that before treatment and in the control group (P<0.05). This study demonstrated that atorvastatin was used to treat patients with diastolic dysfunction and exercise hypertension by lowering blood pressure and reducing exercise SBP, anti-inflammatory and improving vascular endothelial function.