Development and assessment of a brief screening tool for psychosis in dementia

Abstract

Introduction: Hallucinations and delusions (H+D) are common in dementia, but screening for these symptoms—especially in busy clinical practices—is challenging. Methods: Six subject matter experts developed the DRP3™ screen, a novel valid tool to detect H+D in dementia, assessed its content validity through alignment with DRP reference assessments (Scale for the Assessment of Positive Symptoms-Hallucinations + Delusions, Neuropsychiatric Inventory-Questionnaire, International Psychogeriatric Association Criteria), and retrospectively investigated its ability to detect H+D in HARMONY trial (NCT03325556) enrollees. Results: All items from three reference assessments demonstrated significant agreement with the DRP3 screen among raters (P