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Enantioselective Mannich-type reaction catalyzed by a chiral Brønsted acid

Angewandte Chemie - International Edition (2004) 43(12) 1566-1568
DOI: 10.1002/anie.200353240
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Abstract

No metal required: The Mannich-type reaction of ketene silyl acetals 2 with aldimines 1 proceeded highly enantioselectively to afford the syn isomer of β-aminoesters 3 with up to 96% ee under the influence of a chiral Brønsted acid 4 derived from (R)-BINOL.

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Akiyama, T., Itoh, J., Yokota, K., & Fuchibe, K. (2004). Enantioselective Mannich-type reaction catalyzed by a chiral Brønsted acid. Angewandte Chemie - International Edition, 43(12), 1566–1568. https://doi.org/10.1002/anie.200353240

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