Why is there persistent disease despite biologic therapy? Importance of early intervention

Abstract

This short article hypothesizes that the major reason for persistent disease despite biologic therapy is the inappropriately late timing of therapy with biologic agents. There is clear evidence to support this hypothesis. This short review will indicate that patients treated at an earlier phase of disease can achieve a clinical remission rate of 70% and a response rate of above 95%. © 2014 Emery; licensee BioMed Central Ltd.