PRC2 Loss and DNMT Inhibition Boost Viral Mimicry in Cancer

Abstract

In this issue of Cancer Discovery, Patel and colleagues explore the synergistic lethality of PRC2 inactivation and DNMT inhibition in malignant peripheral nerve sheath tumor cells. Reactivation of retrotranspo-sons under this dual control suggests that the viral mimicry response contributes to enhanced cytotoxicity with potential clinical implications.