Selective and sensitive detection of dopamine in the presence of ascorbic acid and uric acid at a Sonogel-Carbon L-Histidine modified electrode

Abstract

The Sonogel-Carbon electrode is a special class of sol-gel electrode that exhibits efficient mechanical and electrical properties. In this study, Sonogel-Carbon modified with L-Histidine was used to prepare a novel electrochemical sensor. This new electrode showed excellent electrocatalytic behavior towards the oxidation of dopamine (DA) in PBS and human serum. The proposed sensor was applied to the simultaneous determination of dopamine, ascorbic acid (AA) and uric acid (UA) in pH 7.4 PBS and excellent results were obtained. A lower detection limit of 1×10-7 M was achieved. This work, illustrates, for first time, the use of L-histidine Sonogel-Carbon electrode as a simple and low-cost tool for the selective and sensitive determination of DA in the presence of AA and UA.