In- situ dissolution testing using different UV fiber optic probes and instruments

Abstract

In-situ dissolution testing using UV fiber optics has attracted much attention in the pharmaceutical industry. Several instruments with different designs of fiber optic probes have been applied for this testing. These instruments employ different types of spectrometers and the probes differ in shape, light beam path, and sampling window. These differences may have significant impact on the dissolution operations and results. In this article we will examine these instruments and probes and discuss the effects of their characteristics on dissolution testing.