Cerebral dynamics and metabolism of hyperpolarized 1- 13 Cpyruvate using time-resolved MR spectroscopic imaging

Abstract

Dynamic hyperpolarized [1- 13C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner. A 12-second bolus injection of hyperpolarized [1- 13C] pyruvate is imaged at a 3-second temporal resolution. The observed dynamics are evaluated with regard to cerebral blood volume (CBV), flow, transport, and metabolic exchange with the cerebral lactate pool. A model for brain [1- 13C]lactate, based on blood-brain transport kinetics, CBV, and the observed pyruvate dynamics is described. © 2010 ISCBFM All rights reserved.