Antihyperuricemic, anti‐inflammatory and antihypertensive effect of a dry extract from solidago virgaurea l. (asteraceae)

Abstract

Solidago virgaurea L. is a perennial plant used in European traditional medicine as a diu-retic or a remedy for inflammatory conditions of the urinary tract but also for gout, especially in the Balkans. The present study was focused on a preclinical, in vivo evaluation of antihyperuricemic, anti‐inflammatory, and antihypertensive effects of a dry extract from S. virgaurea L. (ESV). Colori-metric and HPLC–MS techniques were used to identify the main chemical constituents of ESV. An-tihyperuricemic effect of ESV was assessed in a rat model of hyperuricemia induced by the admin-istration of potassium oxonate. Antihypertensive effect of ESV was evaluated in hyperuricemic rats by monitoring systolic blood pressure with a non‐invasive blood‐pressure recording system. The anti‐inflammatory effect of ESV was tested using a rat model of paw edema. The main chemical constituents of ESV were rutin and phenolic acids represented by chlorogenic and caffeic acid. ESV demonstrated significant antihyperuricemic effects in rats due to an uricosuric mechanism. Addi-tionally, ESV reduced the progression of arterial hypertension in hyperuricemic rats and also showed anti‐inflammatory properties slightly inferior to diclofenac. The results suggest that ESV could be a natural remedy for the treatment of gout and protection against endothelial dysfunction caused by hyperuricemia.