Therapeutic Effect of Epigallocatechin-3-gallate (EGCG) and Silibinin on ATM Dynamics in Prostate Cancer Cell Line LNCaP

Abstract

Epigallocatechin-3-gallate (EGCG) is a major ingredient of green tea (GT) and Silibinin, the active component of Silymarin presumably hold a potential to prevent pathogenomics. Prostate cancer exacerbation is triggered by fusion transcripts formed because of genomicinstability. An abolished ATM dynamics challenges integrity of DNA. Cell lines were analyzed to observe the effect of EGCG and Silibinin on the antiparallel expression profile of TMPRSS2-ERG and ATM In this particular study treatment of the VCaP cell line with EGCG and Silibilin recapitulated ATM expression and activity and down regulated the fusion transcript expression.