2-Oxo-2-polyfluoroalkylethane-1-sulfones and-sulfamides in the three-component reactions leading to pyrimidine derivatives

Abstract

2-Oxo-2-polyfluoroalkylethane-1-sulfones and-sulfamides undergo Biginelli reaction with aryl aldehydes and (thio)urea to give 4-hydroxy-4-polyfluoroalkyl-5-sulfonyl-6-aryltetrahydropyrimidin-2(1H)-(thi)ones, whereas three-component reaction with urea and trialkyl orthoformate provides 4-hydroxy-4-polyfluoroalkyl-5-sulfonyl-3,4-dihydropyrimidin-2(1H)-ones. Some chemical properties of the synthesized pyrimidinones are discussed.